Journal: Experimental Physiology
Article Title: Memory impairment in the D2. mdx mouse model of Duchenne muscular dystrophy is prevented by the adiponectin receptor agonist ALY688
doi: 10.1113/EP091274
Figure Lengend Snippet: Hippocampus and serum inflammatory cytokine expression and contents. (a–d) Hippocampal mRNA fold changes of IL‐6 , IL‐1β , TNF‐α and IL‐10 were expressed relative to wild‐type (WT; D2A) expression. (e–h) Serum levels of IL‐6, IL‐1β, TNF‐α and IL‐10 were quantified. Data are expressed as the mean ± SD, with n = 7–12 per group. * P ≤ 0.05 WT versus D2. mdx ‐VEH; # P ≤ 0.05 WT versus D2 .mdx ‐VEH; § P ≤ 0.05 D2. mdx ‐VEH versus D2. mdx ‐ALY688‐SR. Abbreviations: IL‐6, interleukin‐6; IL‐10, interleukin‐10; IL‐1β, interleukin‐1 beta; TNF‐α, tumor necrosis factor alpha.
Article Snippet: Instead, 3‐week‐old WT DBA/2J WT mice (D2A) were obtained from Jackson Laboratories (stock number 000671; Bar Harbor) and allowed to acclimate in the same room as the D2. mdx mice for 1 week before they were killed.
Techniques: Expressing